Papo Colo’s practice includes painting and graphic design but also extends to performance art and theater. He founded the arts organizations Cultural Space and Trickster Theater in addition to cofounding the interdisciplinary art center Exit Art.

His solo exhibitions include Jumping the Fences, Galeria de la Raza, San Francisco (2009); Paintings, Tyler School of Art, Temple University, Elkins Park, PA (1997); Will, Power, and Desire, 1976–86, Exit Art, New York (1986); Lost and Gained Paradise, Just Above Midtown Gallery, New York (1982); Untitled / Anonymous, El Museo del Barrio, New York (1980); and Contradiction, Spanish Institute, New York (1977).

Select group exhibitions include 100 Years (version #2, ps1, nov 2009), P.S.1 Contemporary Art Center, Long Island City, NY (2009); Negritude, Exit Art, New York (2009); Arte ≠ Vida, El Museo del Barrio, New York (2008); Re-Shuffle: Notions of an Itinerant Museum, Art in General, New York (2006); The Downtown Show, Grey Art Gallery, New York University (2006); globe>miami<island, Bass Museum of Art, Miami Beach, FL (2001); Will/Power, Wexner Center for the Arts, Ohio State University, Columbus (1992); NY: The Next Generation, Carnegie Mellon Art Gallery, Pittsburgh (1991); Out of Abstraction, Islip Art Museum, East Islip, NY (1990); Dirty Pictures, White Columns, New York (1982); Illegal America, Franklin Furnace, New York (1982); Ritual and Rhythm, Kenkeleba House, New York (1982); VARS at JAM, Just Above Midtown Gallery, New York (1981); Marking Black, Bronx Museum of the Arts, Bronx, NY; Variations on Latin Themes in NY, Center for Inter-American Relations, New York (1978); and Roots and Visions, Smithsonian Institute, Washington, DC (1977).